Structural Studies and Antifungal Clathrynamide A and Three New Psammoclemma Sp . Activity of Derivatives JSX Unique Polyene Amides
نویسنده
چکیده
cins,6'ii) and curromycins.i2'i]) In our search for novel antifungal metabolites from marine organisms, 1 was rediscovered from an Okinawan marine sponge of Rsammoclemma sp. as a potent antifungal substance. In addition to 1, we have found three new related metabolites, debromoclathrynamide A (2), (4E,6E)-debromoclathrynamide A (3), and (6E)clathrynamide A (4). This paper reports the first determination of the absolute stereochernistry of 1 and the structural elucidation of new compounds 2-4, as well as their antifungal activities. The results will encourage the synthetic production of these multifunc20N-" x12R
منابع مشابه
Structural studies and antifungal activity of unique polyene amides, clathrynamide A and three new derivatives, from a marine sponge, Psammoclemma sp.
Known polyene amide, clathrynamide A, and three novel related metabolites, debromoclathrynamide A, (4E,6E)-debromoclathrynamide A and (6E)-clathrynamide A, were isolated from an Okinawan marine sponge, Psammoclemma sp. The absolute stereochemistry of clathrynamide A was determined to be 3R,12R by the modified Mosher method. The structures of the three new compounds were elucidated by spectrosco...
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